The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 16, 2019

Filed:

Oct. 29, 2015
Applicant:

Westfaelische Wihelms-universitaet Muenster, Muenster, DE;

Inventors:

Andreas Faust, Billerbeck, DE;

Sven Hermann, Muenster, DE;

Johannes Roth, Muenster, DE;

Michael Schaefers, Havixbeck, DE;

Thomas Vogl, Muenster, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 51/04 (2006.01); A61K 49/00 (2006.01); C07F 13/00 (2006.01); G01N 33/58 (2006.01); G01N 33/60 (2006.01); G01N 33/68 (2006.01); G06T 7/00 (2017.01);
U.S. Cl.
CPC ...
A61K 51/0474 (2013.01); A61K 49/0002 (2013.01); A61K 49/0032 (2013.01); A61K 49/0036 (2013.01); A61K 49/0043 (2013.01); A61K 51/044 (2013.01); C07D 401/14 (2013.01); C07F 13/00 (2013.01); G01N 33/582 (2013.01); G01N 33/60 (2013.01); G01N 33/6893 (2013.01); G06T 7/0014 (2013.01); G01N 2333/4727 (2013.01); G01N 2800/7095 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/10104 (2013.01); G06T 2207/10108 (2013.01); G06T 2207/10132 (2013.01);
Abstract

The present application provides quinoline-3-carboxamide compounds covalently linked to a label for use in the diagnosis of an inflammatory disease at local site. The above mentioned compounds can be used to detect or image accumulation of S100A9 in the body of a subject at sites of inflammation, using in vivo non-invasive molecular imaging techniques for the detection of said compounds. Accordingly, labeled quinoline-3-carboxamide compounds can be applied to evaluate the risk of a subject of developing an inflammatory disease and to follow the progress of the disease.


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