The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Jun. 25, 2013
Applicant:
GE Healthcare As, Oslo, NO;
Inventors:
Svein Kvaale, Oslo, NO;
Ole Johannes Tokerud, Oslo, NO;
Assignee:
GE HEALTHCARE AS, Oslo, NO;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/22 (2006.01); B01J 13/02 (2006.01); B01J 19/24 (2006.01);
U.S. Cl.
CPC ...
A61K 49/223 (2013.01); B01J 13/02 (2013.01); B01J 19/248 (2013.01); B01J 2219/00076 (2013.01); B01J 2219/24 (2013.01);
Abstract
A process for preparing a composition comprising encapsulated gas microbubbles, the process comprising: providing an aqueous protein solution of a heat-denaturable protein at a temperature necessary to achieve incipient denaturation; heating a gas by using heat from the heated protein solution; mixing the heated gas and the heated protein solution to obtain a gas/liquid mixture; and dispersing the gas into the protein solution by subjecting the gas/liquid mixture to mechanical shear forces to form a composition of gas microbubbles encapsulated by denatured protein.