The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Sep. 07, 2012
Applicants:
Edward H. Schuchman, Haworth, NJ (US);
Calogera M. Simonaro, Haworth, NJ (US);
Inventors:
Edward H. Schuchman, Haworth, NJ (US);
Calogera M. Simonaro, Haworth, NJ (US);
Assignee:
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); A61K 38/50 (2006.01); A61K 35/32 (2015.01); A61K 38/18 (2006.01);
U.S. Cl.
CPC ...
A61K 38/50 (2013.01); A61K 35/32 (2013.01); A61K 38/1841 (2013.01); C12N 5/0655 (2013.01); C12Y 305/01023 (2013.01); C12N 2501/73 (2013.01); C12N 2506/1353 (2013.01);
Abstract
The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders. Each of these methods involves treating a cell population with, and/or culturing a cell population in, a ceramidase.