The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 16, 2019

Filed:

Apr. 26, 2016
Applicants:

Ustav Organicke Chemie a Biochemie Akademie Ved Cr, V.v.i., Prague, CZ;

Fyziologicky Ustav Akademie Ved Cr, V.v.i., Prague, CZ;

Inventors:

Lenka Maletinska, Prague, CZ;

Blanka Zelezna, Prague, CZ;

Jaroslav Kunes, Prague, CZ;

Veronika Prazienkova, Tabor, CZ;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/22 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/575 (2006.01); A61K 47/60 (2017.01); A61K 47/54 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/22 (2013.01); A61K 47/542 (2017.08); A61K 47/60 (2017.08); C07K 7/08 (2013.01); C07K 14/001 (2013.01); C07K 14/575 (2013.01); A61K 38/00 (2013.01);
Abstract

Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.


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