The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 16, 2019

Filed:

Mar. 27, 2015
Applicants:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);

Brigham & Women's Hospital, Inc., Boston, MA (US);

Inventors:

Alec C. Kimmelman, Weston, MA (US);

Joseph D. Mancias, Boston, MA (US);

Jeffrey Wade Harper, Wellesley, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 31/713 (2006.01); C12N 15/11 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); A61K 31/713 (2013.01); C12N 15/11 (2013.01); G01N 33/5008 (2013.01); A61K 2121/00 (2013.01);
Abstract

Described herein are methods of modulating autophagic targeting of ferritin in a cell, wherein the method comprises modulating the level and/or activity of nuclear receptor coactivator 4 (NCOA4) in the cell. Also provided are related methods of treatment.


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