The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
May. 20, 2016
Applicant:
Galera Labs, Llc, Creve Coeur, MO (US);
Inventor:
Dennis P. Riley, Chesterfield, MO (US);
Assignee:
Galera Labs, LLC, Creve Coeur, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/395 (2006.01); C07D 471/08 (2006.01); C07D 259/00 (2006.01); A61K 31/4353 (2006.01); A61K 31/555 (2006.01);
U.S. Cl.
CPC ...
A61K 31/395 (2013.01); A61K 31/4353 (2013.01); A61K 31/555 (2013.01); C07D 259/00 (2013.01); C07D 471/08 (2013.01);
Abstract
The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic 16-membered macrocyclic complexes that catalytically dismutate superoxide. It also relates to methods of using these complexes to reduce the concentration or the effects of superoxide, pharmaceutical compositions comprising these compounds or their metal complexes, and methods of treating conditions associated with excessive superoxide activity.