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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10345292 B1

PDFFull Text
Date of Patent:
Jul. 09, 2019

Filed:

Sep. 09, 2015

Mammalian cell lines expressing functional nematode acetylcholine receptors and use thereof for high-throughput screening assays

Applicants:

Merial, Inc., Duluth, GA (US);

Sanofi, Paris, FR;

Inventors:

Lance Hammerland;

Brenda Bondesen, Atlanta, GA (US);

Jean-Marie Chambard, Yerres, FR;

Thierry Vermat, Chazay d'Azergues, FR;

Werner Dittrich, Frankfurt, DE;

Michel Partiseti, Bourg la Reine, FR;

Qing Zhou-Liu, Chennevieres sur Marne, FR;

Cathy Cojean, Massy, FR;

Rachid Boukaiba, Cretail, FR;

Eric Tagat, Sucy en Brie, FR;

Assignees:

BOEHRINGER INGELHEIM ANIMAL HEALTH INC., Duluth, GA (US);

SANOFI, Paris, FR;

Attorneys:

Judy Jarecki-Black

Steffan Finnegan

Primary Examiner:

Neil P Hammell

Int. Cl.
CPC ...
C07K 14/47 (2006.01); G01N 33/50 (2006.01); C07K 14/435 (2006.01); G01N 33/68 (2006.01); C07K 14/705 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
G01N 33/502 (2013.01); C07K 14/4354 (2013.01); C07K 14/4705 (2013.01); C07K 14/70571 (2013.01); C12N 5/0602 (2013.01); G01N 33/6872 (2013.01); C12N 2503/02 (2013.01); C12N 2510/00 (2013.01); G01N 2333/4353 (2013.01); G01N 2333/4706 (2013.01); G01N 2500/10 (2013.01);
Abstract

The following discloses mammalian cells lines that stably express functional nematode acetylcholine receptor subunits. The resulting expression of functional ion channels has been made possible by the stable co-expression of the chaperone protein, RIC3. These cell lines are extremely useful for the high throughput screening (HTS) of compounds, to identify new candidate parasiticidal, including nematocidal, active ingredients.

Find Patent Forward Citations

Hammerland, Lance. (2019). Mammalian cell lines expressing functional nematode acetylcholine receptors and use thereof for high-throughput screening assays (U.S. Patent No. 10345292). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10345292

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