The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Oct. 18, 2013
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
David Putnam, Ithaca, NY (US);
Mingchee Tan, Ithaca, NY (US);
Kirk J. Samaroo, Ithaca, NY (US);
Lawrence J. Bonassar, Ithaca, NY (US);
Assignee:
CORNELL UNIVERSITY, Ithaca, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C10M 107/28 (2006.01); A61K 31/728 (2006.01); A61K 31/48 (2006.01); A61K 31/795 (2006.01); A61L 27/36 (2006.01); A61K 47/66 (2017.01); A61F 2/30 (2006.01);
U.S. Cl.
CPC ...
C10M 107/28 (2013.01); A61K 31/728 (2013.01); A61K 31/795 (2013.01); A61K 47/66 (2017.08); A61L 27/3604 (2013.01); A61L 27/3695 (2013.01); A61F 2/30756 (2013.01); A61F 2002/30673 (2013.01); A61F 2002/30754 (2013.01); A61L 2400/06 (2013.01); A61L 2430/24 (2013.01);
Abstract
This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) backbones grafted with polyethylene glycol.