The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 09, 2019

Filed:

Feb. 24, 2017
Applicants:

Deutsches Krebsforschungszentrum, Heidelberg, DE;

Ruprecht-karls Universitaet, Heidelberg, DE;

Inventors:

Guy Ungerechts, Heidelberg, DE;

Christine Engeland, Heidelberg, DE;

Ruta Veinalde, Heidelberg, DE;

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 14/54 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5434 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 16/2887 (2013.01); C07K 16/3007 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); A61K 2039/5256 (2013.01); C07K 2317/622 (2013.01); C12N 2760/18043 (2013.01); C12N 2760/18432 (2013.01); C12N 2760/18443 (2013.01);
Abstract

The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding an IL-12 polypeptide, wherein said IL-12 polypeptide is an IL-12 fusion polypeptide comprising a p35 subunit of an IL-12 and a p40 subunit of an IL-12; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.


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