The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Dec. 11, 2015
Forschungsverbund Berlin E.v., Berlin, DE;
Universität Zu Köln, Köln, DE;
Ronald Kühne, Berlin, DE;
Hans-Günther Schmalz, Brühl, DE;
Matthias Müller, Berlin, DE;
Cedric Reuter, Köln, DE;
Arne Soicke, Overath, DE;
Robert Opitz, Berlin, DE;
Matthias Barone, Berlin, DE;
Hartmut Oschkinat, Berlin, DE;
FORSCHUNGSVERBUND BERLIN E.V., Berlin, DE;
UNIVERSITÄT ZU KÖLN, Köln, DE;
Abstract
The present invention relates to chemical compounds that can in particular be used as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of said compounds as pharmaceutical agents and to the use of the pharmaceutical agents to treat tumor diseases. The chemical compounds of the present invention can significantly inhibit the chemotaxis and motility of invasive tumor cells and can therefore be used in the treatment and/or prevention of tumor metastases.