The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Nov. 27, 2017
Applicant:
Kindex Pharmaceuticals, Inc., Seattle, WA (US);
Inventors:
Veera Konda, Bellevue, WA (US);
Jan Urban, Port Orchard, WA (US);
Anuradha Desai, Bellevue, WA (US);
Clinton J. Dahlberg, Port Orchard, WA (US);
Brian J. Carroll, Gig Harbor, WA (US);
Assignee:
KINDEX PHARMACEUTICALS, INC., Seattle, WA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 225/14 (2006.01); A61K 31/122 (2006.01); A61K 31/135 (2006.01); C07C 59/90 (2006.01); C07C 69/78 (2006.01); C07C 69/96 (2006.01); C07C 69/28 (2006.01); C07C 69/612 (2006.01); C07C 49/707 (2006.01); C07C 49/743 (2006.01); C07C 251/42 (2006.01);
U.S. Cl.
CPC ...
C07C 225/14 (2013.01); A61K 31/122 (2013.01); A61K 31/135 (2013.01); C07C 49/707 (2013.01); C07C 49/743 (2013.01); C07C 59/90 (2013.01); C07C 69/28 (2013.01); C07C 69/612 (2013.01); C07C 69/78 (2013.01); C07C 69/96 (2013.01); C07C 251/42 (2013.01); C07C 2601/08 (2017.05); C07C 2601/10 (2017.05);
Abstract
The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.