The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Sep. 07, 2017
The Regents of the University of California, Oakland, CA (US);
Jeffrey I. Zink, Sherman Oaks, CA (US);
Andre E. Nel, Sherman Oaks, CA (US);
Tian Xia, Los Angeles, CA (US);
Zhaoxia Ji, Wellesley, MA (US);
Huan Meng, Los Angeles, CA (US);
Zongxi Li, Boston, MA (US);
Monty Liong, Foster City, CA (US);
Min Xue, Chino Hills, CA (US);
Derrick Y. Tarn, Santa Ana, CA (US);
Sanaz Gardner, Los Angeles, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.