The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Jan. 20, 2017
Applicant:
Holy Stone Healthcare Co., Ltd., Taipei, TW;
Inventor:
Hua-Yang Lin, Taipei, TW;
Assignee:
HOLY STONE HEALTHCARE CO., LTD., Taipei, TW;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/61 (2017.01); A61K 31/145 (2006.01); A61K 31/18 (2006.01); A61K 31/415 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/573 (2006.01); A61K 31/7068 (2006.01); A61K 31/728 (2006.01); A61K 47/48 (2006.01); A61K 31/635 (2006.01);
U.S. Cl.
CPC ...
A61K 47/4823 (2013.01); A61K 31/145 (2013.01); A61K 31/18 (2013.01); A61K 31/415 (2013.01); A61K 31/445 (2013.01); A61K 31/454 (2013.01); A61K 31/573 (2013.01); A61K 31/635 (2013.01); A61K 31/7068 (2013.01); A61K 31/728 (2013.01); A61K 47/61 (2017.08);
Abstract
The present invention is related to a compound conjugating a drug with a glycosaminoglycan, such as hyaluronic acid (HA), where the drug is useful for the treatment of diseases such as inflammation, auto-immune disease, allergy, infection and preferably cancer. The conjugated compound of the present invention can increase the concentration of drug at the specific site of disease by an interaction of the glycosaminoglycan used as target drug delivery carrier and the CD44 cell surface receptor, then enhancing the therapeutic efficacy and reducing the systemic side effect of the site-delivered drug.