logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10342819 B1

PDFFull Text
Date of Patent:
Jul. 09, 2019

Filed:

Mar. 03, 2015

Oligonucleotide having non-natural nucleotide at 5'-terminal thereof

Applicant:

Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;

Inventors:

Fumikazu Shinohara, Tokyo, JP;

Asana Makino, Tokyo, JP;

Junichiro Yamamoto, Tokyo, JP;

Takahiro Nakajima, Tokyo, JP;

Taiji Oashi, Tokyo, JP;

Michihiko Suzuki, Tokyo, JP;

Jun-ichi Saito, Tokyo, JP;

Tomoyuki Nishikawa, Tokyo, JP;

Masayoshi Nakoji, Tokyo, JP;

Yuichi Takahashi, Tokyo, JP;

Yasuo Kouda, Tokyo, JP;

Assignee:

KYOWA HAKKO KIRIN CO., LTD., Tokyo, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Pancham Bakshi

Int. Cl.
CPC ...
A61K 31/7115 (2006.01); A61K 31/7076 (2006.01); A61K 31/713 (2006.01); C07H 19/16 (2006.01); C07H 19/167 (2006.01); C07H 19/173 (2006.01); C07H 19/20 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07H 21/00 (2006.01); C07H 23/00 (2006.01); C12N 15/113 (2010.01); A61K 31/5377 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7115 (2013.01); A61K 31/5377 (2013.01); A61K 31/7076 (2013.01); A61K 31/713 (2013.01); C07H 19/06 (2013.01); C07H 19/10 (2013.01); C07H 19/16 (2013.01); C07H 19/167 (2013.01); C07H 19/173 (2013.01); C07H 19/20 (2013.01); C07H 21/00 (2013.01); C07H 23/00 (2013.01); C12N 15/113 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/32 (2013.01); C12N 2310/33 (2013.01); C12N 2320/31 (2013.01);
Abstract

An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein Xis an oxygen atom or the like, Ris formula (IIA) (wherein Ris halogen or the like, and Ris a hydrogen atom or the like), formula (IVA) (wherein Yis a nitrogen atom or the like, and Yis CH or the like), or the like, Ris a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and Ris a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5' end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.

Find Patent Forward Citations

Loading…