The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 09, 2019

Filed:

Mar. 26, 2015
Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61K 31/4409 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/4409 (2013.01); A61K 31/519 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives of formula (I) and also compounds of formula (I') wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as ROS1 inhibitors. The invention further relates to processes for preparing novel compounds of the present invention, pharmaceutical compositions comprising compounds of the present invention as an active ingredient as well as the use of compounds of the present invention as a medicament.


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