The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
May. 05, 2017
Deutsches Rheuma-forschungszentrum Berlin, Berlin, DE;
A⋅p⋅e Angewandte Physik & Elektronik Gmbh, Berlin, DE;
Kristen Feher, Berlin, DE;
Toralf Kaiser, Birkenwerder, DE;
Konrad von Volkmann, Berlin, DE;
Sebastian Wolf, Berlin, DE;
Deutsches Rheuma-Forschungszentrum Berlin, Berlin, DE;
A⋅P⋅E Angewandte Physik & Elektronik GmbH, Berlin, DE;
Abstract
The invention relates to a method and system for characterizing particles using a flow cytometer comprising generating a waveform, as a digital representation of detected radiated light, and transforming said waveform using one or more basis functions and obtaining one or more coefficients characterizing the waveform. The one or more coefficients characterizing the waveform preferably correspond to particular properties of the particle(s), thereby enabling analysis of physical properties of the particles (such as size or shape) or biological properties of the particles, such as cell type, localization and/or distribution of molecules within the cell and/or on the cell surface, structural elements of the cell such as the nucleus or the cytoskeleton, antibody or antibody-fragment binding to the cell or cell morphology. Preferred embodiments of the invention relate to methods and systems in which the waveform is transformed by a wavelet transformation or Fourier transformation.