The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
Feb. 08, 2017
Applicant:
Qiagen Waltham, Inc., Waltham, MA (US);
Inventors:
Jerzy Olejnik, Brookline, MA (US);
Michel Georges Perbost, Belmont, MA (US);
Assignee:
Qiagen Sciences, LLC, Germantown, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6823 (2018.01); C12Q 1/6869 (2018.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6823 (2013.01); C12Q 1/6869 (2013.01);
Abstract
The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods. In particular, the present invention contemplates the use of polyphenolic compounds, known as antioxidant additives, to improve the efficiency of Sequencing-By-Synthesis reactions. For example, gallic acid (GA) is shown herein to be one of many exemplary SBS polyphenolic additives.