The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
Aug. 05, 2015
Applicant:
Mohammed Zourob, Riyadh, SA;
Inventor:
Mohammed Zourob, Riyadh, SA;
Assignee:
Alfaisal University, Riyadh, SA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/37 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); G01N 2333/96433 (2013.01); G01N 2446/20 (2013.01); G01N 2446/80 (2013.01); G01N 2800/18 (2013.01); G01N 2800/26 (2013.01);
Abstract
A multiplex hand-held diagnostic biosensor, using two inflammatory salivary biomarkers, Human Neutrophil Elastase (HNE) and Cathepsin-G, was constructed made to potentially detect Periodontitis at an early stage is described. The use of magnetic nanoparticle biosensor method used as a device was based on the measurement of proteolytic activity using specific proteases probes. The magnetic nanoparticle biosensor device is capable of specific and quantitative detection of HNE and Cathepsin-G in solution and in spiked saliva samples with a lower detection limit of 1 pg/mL and 100 fg/mL for HNE and Cathepsin-G, respectively.