The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2019

Filed:

May. 21, 2015
Applicants:

Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;

Cnrs (Centre National DE LA Recherche Scientifique), Paris, FR;

Universite DE Strasbourg, Strasbourg, FR;

Cornell University, Ithaca, NY (US);

Universite Paris-sud Xi, Orsay, FR;

Assistance Publique-hopitaux DE Paris (Aphp), Paris, FR;

Inventors:

Helene Monique Puccio, Illkirch, FR;

Patrick Aubourg, Le Kremlin Bicetre, FR;

Ronald G. Crystal, New York, NY (US);

Pierre Bougneres, Le Kremlin Bicetre, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/867 (2006.01); A61K 48/00 (2006.01); A61K 38/43 (2006.01); A61K 35/765 (2015.01); A61K 31/713 (2006.01); C12N 15/52 (2006.01); C12N 15/86 (2006.01); A61K 31/7088 (2006.01); A61K 38/44 (2006.01); C12N 7/00 (2006.01); A61K 9/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 9/0019 (2013.01); A61K 31/7088 (2013.01); A61K 38/44 (2013.01); A61K 48/005 (2013.01); A61K 48/0016 (2013.01); C07K 14/47 (2013.01); C12N 7/00 (2013.01); A61K 48/00 (2013.01); C12N 2750/14032 (2013.01); C12N 2750/14071 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01); C12Y 116/03001 (2013.01);
Abstract

A method for preventing or treating cardiomyopathy due to energy failure in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of a vector which comprises a nucleic acid sequence encoding a gene that can reverse energy failure. An exemplary cardiomyopathy is that which is associated with Friedreich ataxia and an exemplary nucleic acid sequence comprises a nucleic acid that encodes frataxin (FXN).


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