The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
Dec. 15, 2015
Bonac Corporation, Kurume-shi, Fukuoka, JP;
Takahiro Matsumoto, Kurume, JP;
Hidekazu Toyofuku, Kurume, JP;
BONAC CORPORATION, Kurume, JP;
Abstract
The invention provides a single-stranded nucleic acid molecule of (A) or (B) containing a TGF-β1 gene expression inhibitory sequence. The single-stranded nucleic acid molecule (A) consists of region (Xc), linker region (Lx) and region (X) from the 5'-side to the 3′-side, wherein linker region (Lx) has a non-nucleotide structure containing at least one of a pyrrolidine skeleton and a piperidine skeleton, and at least one of region (X) and region (Xc) contains the expression inhibitory sequence. The single-stranded nucleic acid molecule (B) contains region (Xc), linker region (Lx), region (X), region (Y), linker region (Ly) and region (Yc) from the 5′-side to the 3′-side, wherein region (X) and region (Y) are linked to form inner region (Z), region (Xc) is complementary to region (X), region (Yc) is complementary to region (Y), linker region (Lx) and linker region (Ly) each have a non-nucleotide structure containing at least one of a pyrrolidine skeleton and a piperidine skeleton, and inner region (Z) contains the expression inhibitory sequence.