The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
Feb. 11, 2016
Applicants:
University Health Network, Toronto, CA;
Takara Bio Inc., Shiga, JP;
Inventors:
Assignees:
University Health Network, Toronto, CA;
Takara Bio Inc., Shiga, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/00 (2006.01); A61K 38/00 (2006.01); C07K 16/28 (2006.01); C12N 15/62 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7155 (2013.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 16/2803 (2013.01); C12N 15/62 (2013.01); A61K 35/00 (2013.01); A61K 38/00 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01);
Abstract
Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a Signal Transducer and Activator of Transcription (STAT) 5 association motif and/or a CD3ζ intracellular signaling domain comprising an exogenous STAT3 association motif, as well as cells and 5 compositions comprising said CARs and uses thereof.