The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2019

Filed:

Nov. 22, 2010
Applicants:

J. Timothy Stout, Portland, OR (US);

Binoy Appukuttan, Portland, OR (US);

Trevor Mcfarland, Portland, OR (US);

Inventors:

J. Timothy Stout, Portland, OR (US);

Binoy Appukuttan, Portland, OR (US);

Trevor McFarland, Portland, OR (US);

Assignee:

Research Development Foundation, Carson City, NV (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 8/64 (2006.01); A61K 38/00 (2006.01); A61Q 17/04 (2006.01); A61Q 19/00 (2006.01); A61Q 19/04 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4713 (2013.01); A61K 8/64 (2013.01); A61Q 19/005 (2013.01); A61Q 19/008 (2013.01); A61K 38/00 (2013.01); A61Q 17/04 (2013.01); A61Q 19/00 (2013.01); A61Q 19/04 (2013.01);
Abstract

Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.


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