The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2019

Filed:

Jun. 15, 2015
Applicants:

Yuma Therapeutics, Inc., Cambridge, MA (US);

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Inventors:

Gregory D. Cuny, Houston, TX (US);

Marcie A. Glicksman, Boston, MA (US);

Kevin J. Hodgetts, Framingham, MA (US);

Steven L. Mathieu, Somerville, MA (US);

Yukari Y. Perrella, Cambridge, MA (US);

Vincent Darmency, Bougy Villars, CH;

Hrvoje Lusic, Boston, MA (US);

Assignees:

Yuma Therapeutics, Inc., Cambridge, MA (US);

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/04 (2006.01); C07D 487/04 (2006.01); C07D 405/04 (2006.01); C07D 239/42 (2006.01); C07D 239/70 (2006.01); C07D 471/04 (2006.01); C07D 239/84 (2006.01); C07D 251/16 (2006.01); C07D 251/22 (2006.01); C07D 405/10 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); C07D 239/42 (2013.01); C07D 239/70 (2013.01); C07D 239/84 (2013.01); C07D 251/16 (2013.01); C07D 251/22 (2013.01); C07D 405/04 (2013.01); C07D 405/10 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to 2-amino-4-arylpyrimidine and 2-amino-4-aryltriazine compounds as inhibitors of heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention. The invention further relates to the medical use of these compounds and compositions for the treatment of a disorder in a subject. For example, the disorder is a neurodegenerative disease.


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