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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10336717 B1

PDFFull Text
Date of Patent:
Jul. 02, 2019

Filed:

Oct. 15, 2015

Inhibitors of beta-secretase

Applicant:

Vitae Pharmaceuticals, Inc., Fort Washington, PA (US);

Inventors:

Salvacion Cacatian, Conshohocken, PA (US);

David A. Claremon, Maple Glen, PA (US);

Lawrence Wayne Dillard, Yardley, PA (US);

Klaus Fuchs, Ingelheim am Rhein, DE;

Niklas Heine, Ingelheim am Rhein, DE;

Lanqi Jia, Horsham, PA (US);

Katerina Leftheris, San Diego, CA (US);

Brian McKeever, Lake Ronkonkoma, NY (US);

Angel Morales-Ramos, Blue Bell, PA (US);

Suresh B. Singh, Kendall Park, NJ (US);

Shankar Venkatraman, Lansdale, PA (US);

Guosheng Wu, Yardley, PA (US);

Zhongren Wu, Audubon, PA (US);

Zhenrong Xu, Chalfont, PA (US);

Jing Yuan, Lansdale, PA (US);

Yajun Zheng, Hockessin, DE (US);

Assignee:

Vitae Pharmaceuticals, LLC, Wilmington, DE (US);

Attorney:

Andrew Chien

Primary Examiner:

Kara R McMillian

Int. Cl.
CPC ...
C07D 233/46 (2006.01); C07D 235/02 (2006.01); C07D 239/70 (2006.01); C07D 271/12 (2006.01); C07D 277/60 (2006.01); C07D 279/08 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/04 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 417/04 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 487/10 (2006.01); C07D 491/10 (2006.01); C07D 493/20 (2006.01); C07D 495/10 (2006.01); C07D 498/10 (2006.01); C07D 513/10 (2006.01);
U.S. Cl.
CPC ...
C07D 271/12 (2013.01); C07D 233/46 (2013.01); C07D 235/02 (2013.01); C07D 239/70 (2013.01); C07D 277/60 (2013.01); C07D 279/08 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 413/04 (2013.01); C07D 413/06 (2013.01); C07D 417/04 (2013.01); C07D 417/06 (2013.01); C07D 417/10 (2013.01); C07D 487/10 (2013.01); C07D 491/10 (2013.01); C07D 493/20 (2013.01); C07D 495/10 (2013.01); C07D 498/10 (2013.01); C07D 513/10 (2013.01);
Abstract

The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.

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