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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10335515 B1

PDFFull Text
Date of Patent:
Jul. 02, 2019

Filed:

Oct. 20, 2015

Hydrogel precursors having nanoparticles

Applicant:

The University of Kansas, Lawrence, KS (US);

Inventors:

Michael Detamore, Lawrence, KS (US);

Emily Beck, Lawrence, KS (US);

Stevin Gehrke, Lawrence, KS (US);

Cory Berkland, Lawrence, KS (US);

Assignee:

The University of Kansas, Lawrence, KS (US);

Attorney:

Maschoff Brennan

Primary Examiner:

Matthew P Coughlin

Assistant Examiner:

Thurman Wheeler

Int. Cl.
CPC ...
A61L 27/48 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 27/20 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01);
U.S. Cl.
CPC ...
A61L 27/48 (2013.01); A61L 27/20 (2013.01); A61L 27/383 (2013.01); A61L 27/3817 (2013.01); A61L 27/3834 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 2430/06 (2013.01); A61L 2430/32 (2013.01);
Abstract

An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.

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