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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10335499 B1

PDFFull Text
Date of Patent:
Jul. 02, 2019

Filed:

Feb. 05, 2016

Block copolymers and uses thereof

Applicant:

École Polytechnique Fédérale DE Lausanne (Epfl), Lausanne, CH;

Inventors:

James Brandon Dixon, Marietta, GA (US);

Jeffrey A. Hubbell, Préverenges, CH;

Conlin P. O'Neil, Chavannes-renens, CH;

Melody Swartz, Préverenges, CH;

Diana Velluto, London, GB;

Assignee:

École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH;

Attorney:

Clark & Elbing LLP

Primary Examiner:

Isaac Shomer

Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 47/10 (2017.01); A61K 47/34 (2017.01); C08L 71/02 (2006.01); C08L 81/00 (2006.01); C08L 81/02 (2006.01); A61K 47/22 (2006.01); A61K 48/00 (2006.01); A61K 9/107 (2006.01); A61K 9/127 (2006.01); C08G 75/08 (2006.01); C08G 83/00 (2006.01); A61K 31/337 (2006.01); A61K 31/573 (2006.01); A61K 31/713 (2006.01); C08G 65/329 (2006.01); C08G 65/334 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0041 (2013.01); A61K 9/1075 (2013.01); A61K 9/1273 (2013.01); A61K 9/5146 (2013.01); A61K 31/337 (2013.01); A61K 31/573 (2013.01); A61K 31/713 (2013.01); A61K 47/10 (2013.01); A61K 47/22 (2013.01); A61K 47/34 (2013.01); C07K 16/00 (2013.01); C08G 65/329 (2013.01); C08G 65/3344 (2013.01); C08G 75/08 (2013.01); C08G 83/008 (2013.01); C08L 71/02 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C08L 81/02 (2013.01); C08L 2203/02 (2013.01); C08L 2205/05 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/16 (2013.01); C12N 2320/32 (2013.01); Y02A 50/387 (2018.01); Y10S 977/773 (2013.01); Y10S 977/906 (2013.01); Y10S 977/916 (2013.01);
Abstract

Block copolymers containing charged blocks or chemical moieties sensitive to oxidation or hydrolysis have been developed. We describe the use of such block copolymers in supramolecular structures, e.g., micelles or vesicles, and pharmaceutical compositions and in methods of preparing the supramolecular structures and pharmaceutical compositions. The invention is particularly useful for the delivery of pharmaceutical agents, e.g., nucleic acids, to cells.

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