The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 2019

Filed:

Aug. 12, 2013
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Brian Gillette, Bronx, NY (US);

Samuel Sia, New York, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/12 (2015.01); A61K 35/35 (2015.01); A61K 35/44 (2015.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 35/35 (2013.01); A61K 35/12 (2013.01); A61K 35/44 (2013.01); C12N 5/0653 (2013.01); C12N 2502/28 (2013.01); C12N 2506/1384 (2013.01); C12N 2513/00 (2013.01);
Abstract

Provided are methods, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes by administration of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues to a subject, where the microtissues comprise adipose stem cells and endothelial cells. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3D cell aggregates.


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