The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
Aug. 02, 2016
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Hai-Yun Xiao, Belle Mead, NJ (US);
T.G. Murali Dhar, Newton, PA (US);
Bin Jiang, Bryn Mawr, PA (US);
Jingwu Duan, Yardley, PA (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 487/14 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61P 37/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4184 (2013.01); A61K 31/4188 (2013.01); A61P 37/02 (2018.01); C07D 487/04 (2013.01); C07D 487/14 (2013.01);
Abstract
Disclosed are compounds of Formula (I) or a salt thereof, wherein: Ring A is 3- to 6-membered carbocyclic or heterocyclic ring; X is CRor N; Y is —(CRR)—; Z is —(CRR)—; and q, R, R, R, R, R, R, R, R, and Rare defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.