The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2019

Filed:

Nov. 12, 2015
Applicant:

Technische Universiteit Eindhoven, Eindhoven, NL;

Inventors:

Peter Zijlstra, Utrecht, NL;

Menno Willem José Prins, Rosmalen, NL;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); G01N 33/543 (2006.01); G01N 33/542 (2006.01); C12Q 1/6825 (2018.01); G01N 21/552 (2014.01);
U.S. Cl.
CPC ...
G01N 33/54373 (2013.01); C12Q 1/6825 (2013.01); G01N 21/554 (2013.01); G01N 33/542 (2013.01); G01N 33/5436 (2013.01); G01N 33/54346 (2013.01);
Abstract

A target analyte in a matrix is sensed using a sensor device having protrusions [] such as e.g. nanorods, containing free charge carriers. Conformational molecules [] are bound at a first end to the protrusions, and bound at a second end to a label [] e.g. a nanoparticle, that is free to move relative to the protrusions. The conformational molecule changes its conformation when bound to the analyte, thereby changing the distance and/or the relative orientation of the label to the protrusion. Energy [] is used to excite free electrons in the protrusion near a plasmon resonance and resulting optical radiation [] at wavelengths near the plasmon resonance wavelength is detected [] and analyzed [] to determined the presence/concentration of the analyte.


Find Patent Forward Citations

Loading…