The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Jun. 27, 2017
Applicants:
Seattle Genetics, Inc., Bothell, WA (US);
Medimmune Limited, Cambridge, England, GB;
Inventors:
Assignees:
SEATTLE GENETICS, INC., Bothell, WA (US);
MEDIMMUNE LIMITED, Cambridge, GB;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07K 16/28 (2006.01); C07D 519/00 (2006.01); A61K 31/5517 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/2875 (2013.01); A61K 31/5517 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); C07D 487/04 (2013.01); C07D 519/00 (2013.01); Y02A 50/385 (2018.01); Y02A 50/414 (2018.01); Y02A 50/423 (2018.01);
Abstract
This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.