The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Sep. 12, 2016
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Intezyne Technologies Inc., Tampa, FL (US);
Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);
Board of Regents, University of Texas System, Austin, TX (US);
Robert J. Gillies, Tampa, FL (US);
David L. Morse, Tampa, FL (US);
Natalie M. Barkey, Tampa, FL (US);
Kevin N. Sill, Tampa, FL (US);
Josef Vagner, Tucson, AZ (US);
Narges K. Tafreshi, Tampa, FL (US);
Jonathan L. Sessler, Austin, TX (US);
Christian Preihs, Austin, TX (US);
Victor J. Hruby, Tucson, AZ (US);
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US);
BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US);
INTEZYNE TECHNOLOGIES INC., Tampa, FL (US);
Abstract
The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.