The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Aug. 22, 2014
Applicants:
Duke University, Durham, NC (US);
The Regents of the University of California, Oakland, CA (US);
Inventors:
Wolfgang Liedtke, Durham, NC (US);
Farshid Guilak, Clayton, MO (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/4436 (2006.01); C07D 277/42 (2006.01); C07D 401/04 (2006.01); C07D 417/04 (2006.01); C07D 277/20 (2006.01); A61K 31/4439 (2006.01); A01K 67/027 (2006.01); A61K 9/00 (2006.01); A61K 49/00 (2006.01); C07D 519/00 (2006.01); C07K 14/705 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07D 277/20 (2013.01); A01K 67/0276 (2013.01); A61K 9/0014 (2013.01); A61K 31/426 (2013.01); A61K 31/4439 (2013.01); A61K 49/0008 (2013.01); C07D 519/00 (2013.01); C07K 14/705 (2013.01); G01N 33/6872 (2013.01); G01N 33/6881 (2013.01); A01K 2217/075 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0356 (2013.01); G01N 2333/4703 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01);
Abstract
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.