The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2019

Filed:

Jun. 22, 2018
Applicant:

Mitsubishi Tanabe Pharma Corporation, Osaka-shi, Osaka, JP;

Inventors:

Hideki Ushirogochi, Osaka, JP;

Wataru Sasaki, Osaka, JP;

Yuichi Onda, Osaka, JP;

Ryo Sakakibara, Osaka, JP;

Fumihiko Akahoshi, Osaka, JP;

Assignee:

MITSUBISHI TANABE PHARMA CORPORATION, Osaka-shi, Osaka, JP;

Attorney:
Int. Cl.
CPC ...
C07D 253/07 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); A61K 31/53 (2006.01); A61P 9/04 (2006.01); A61P 13/12 (2006.01); C07D 403/12 (2006.01); C07D 413/14 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/553 (2006.01); C07D 401/12 (2006.01); C07D 405/04 (2006.01); C07D 405/12 (2006.01); C07D 409/04 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/04 (2006.01); C07D 453/02 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 253/06 (2006.01); C07D 498/08 (2006.01); C07D 498/10 (2006.01); C07D 451/02 (2006.01);
U.S. Cl.
CPC ...
C07D 253/07 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/553 (2013.01); A61P 9/04 (2018.01); A61P 13/12 (2018.01); C07D 253/06 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 451/02 (2013.01); C07D 453/02 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 498/08 (2013.01); C07D 498/10 (2013.01);
Abstract

This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein Ris, for example, a group of the following formula (A-1): wherein ring Ais, for example, a cycloalkyl group which may be substituted,and Ris, for example, a monocyclic cycloalkyl group,or a pharmaceutically acceptable salt thereof.


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