The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Apr. 26, 2016
Applicant:
University of Washington, Seattle, WA (US);
Inventors:
Keith Elkon, Seattle, WA (US);
Jie An, Seattle, WA (US);
Mark Minie, Seattle, WA (US);
Tomikazu Sasaki, Seattle, WA (US);
Joshua J. Woodward, Seattle, WA (US);
Assignee:
UNIVERSITY OF WASHINGTON, Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 219/12 (2006.01); A61K 31/4353 (2006.01); C07D 403/12 (2006.01); C07D 219/10 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 219/12 (2013.01); A61K 31/4353 (2013.01); C07D 219/10 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01);
Abstract
The present invention provides therapeutic strategies for treatment of severe debilitating diseases associated with IFN-I due to cGAS activation. In one aspect, the invention provides compounds of Formula (I): [Formula should be inserted here] and pharmaceutical uses thereof. In another aspect, the invention provides methods for treating an autoimmune disease or a monogenic disorder by administering an effective amount of a compound of Formula (I).