The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Apr. 20, 2016
Applicant:
Aop Orphan Pharmaceuticals Ag, Vienna, AT;
Inventors:
Enrica Diodato, Siena, IT;
Katia Marcucci, Siena, IT;
Russell Thomas, Siena, IT;
Paul Wiedenau, Siena, IT;
Martin Rettig, Schwanau-nonnenweier, DE;
Huw Roberts, Flint Wales, GB;
Assignee:
AOP ORPHAN PHARMACEUTICALS AG, Vienna, AT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/88 (2006.01);
U.S. Cl.
CPC ...
C07D 209/88 (2013.01);
Abstract
The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable polymorphic form, through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester, which in turn is processed to yield the final product.