The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2019

Filed:

Oct. 03, 2018
Applicant:

King Saud University, Riyadh, SA;

Inventors:

Mashooq Ahmad Bhat, Riyadh, SA;

Mohamed A. Al-Omar, Riyadh, SA;

Nawaf Abdulaziz Alsaif, Riyadh, SA;

Syed Hidayathulla, Riyadh, SA;

Assignee:

King Saud University, Riyadh, SA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 325/02 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07C 325/02 (2013.01); A61P 29/00 (2018.01); C07C 2602/08 (2017.05);
Abstract

The sulindac derivatives are compounds of the formula: wherein R is one of twenty-five substituted or unsubstituted phenyl substituents; and pharmaceutically acceptable salts thereof. The sulindac derivatives are synthesized by refluxing sulindac hydrazide with appropriately substituted benzaldehydes in the presence of ethanol and catalytic amounts of glacial acetic acid. The sulindac derivatives may be used as active ingredients in pharmaceutical compositions for the treatment of inflammation or inflammatory diseases. The sulindac derivatives may also be used as analgesic and/or gastric sparing agents.


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