The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Mar. 22, 2018
Applicant:
King Fahd University of Petroleum and Minerals, Dhahran, SA;
Inventors:
Assignee:
King Fahd University of Petroleum and Minerals, Dhahran, SA;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61K 31/198 (2006.01); C07C 227/16 (2006.01); C07C 229/36 (2006.01); C07C 231/12 (2006.01); C07C 233/51 (2006.01);
U.S. Cl.
CPC ...
C07C 231/12 (2013.01); A61K 31/198 (2013.01); A61K 38/191 (2013.01); C07C 227/16 (2013.01);
Abstract
A method for producing a compound of formula (I) or a pharmaceutically acceptable salt, solvate, tautomer or stereoisomer, such as compound 1 and compound 2 is disclosed. The method proceeds through an O-allylated tyrosine-based compound, such as compound 3 and preferably comprises [3,3] sigmatropic Claisen rearrangement and olefin cross metathesis reactions. In addition, a pharmaceutical composition comprising a compound of formula (I) a tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL) and a pharmaceutically acceptable carrier or excipient is disclosed.