The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2019

Filed:

Mar. 18, 2015
Applicant:

Warsaw Orthopedic, Inc., Warsaw, IN (US);

Inventors:

Keyvan Behnam, Red Bank, NJ (US);

David Knaack, Red Bank, NJ (US);

Assignee:

Warsaw Orthopedic, Inc., Warsaw, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61K 35/32 (2015.01); A61K 38/01 (2006.01); A61K 38/18 (2006.01); A61L 27/12 (2006.01); A61L 27/42 (2006.01); A61L 27/48 (2006.01); A61L 27/54 (2006.01); C07K 14/51 (2006.01); A61F 2/28 (2006.01); A61F 2/30 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3608 (2013.01); A61K 35/32 (2013.01); A61K 38/012 (2013.01); A61K 38/1875 (2013.01); A61L 27/12 (2013.01); A61L 27/365 (2013.01); A61L 27/3683 (2013.01); A61L 27/3687 (2013.01); A61L 27/425 (2013.01); A61L 27/48 (2013.01); A61L 27/54 (2013.01); C07K 14/51 (2013.01); A61F 2/28 (2013.01); A61F 2002/2817 (2013.01); A61F 2002/2835 (2013.01); A61F 2002/30677 (2013.01); A61F 2310/00359 (2013.01); A61L 2300/252 (2013.01); A61L 2300/414 (2013.01); A61L 2300/802 (2013.01); A61L 2430/02 (2013.01); A61L 2430/40 (2013.01);
Abstract

An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.


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