The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2019

Filed:

Jan. 14, 2016
Applicants:

Ashok K. Chopra, League City, TX (US);

Jian Sha, League City, TX (US);

Inventors:

Ashok K. Chopra, League City, TX (US);

Jian Sha, League City, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 13/00 (2006.01); A61K 39/02 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0291 (2013.01); A61K 45/06 (2013.01); A61K 2039/522 (2013.01); A61K 2039/572 (2013.01);
Abstract

Provided herein is a genetically modifiedthat includes three alterations compared to a control. Two alterations include decreased mRNA, decreased protein, or a combination thereof, encoded by a lpp coding region and encoded by a msbB coding region. The third alteration is selected from an alteration of an intergenic region between the coding regions ypo1119 and ypo1120, and decreased mRNA, decreased protein, or a combination thereof, encoded by a coding region selected from pla, ypol717, ypmt1.80c, rbsA (ypo2500), ypo0498, vasK (ypo3603), ypo3164, hxuB (ypo3248), ypo1616, ypo1119, ypo1120, and ail. Also provided are compositions that include the genetically modified, and methods of using the genetically modified


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