The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Dec. 05, 2014
Acerta Pharma B.v., Oss, NL;
Ahmed Hamdy, Santa Cruz, CA (US);
Wayne Rothbaum, New York, NY (US);
Raquel Izumi, San Carlos, CA (US);
Brian Lannutti, Solana Beach, CA (US);
Todd Covey, San Carlos, CA (US);
Roger Ulrich, Sammamish, WA (US);
Dave Johnson, Aptos, CA (US);
Tjeerd Barf, Ravenstein, NL;
Allard Kaptein, Zaltbommel, NL;
Acerta Pharma, B.V., Oss, NL;
Abstract
In some embodiments, the invention includes a therapeutic combination of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the γ- and δ-isoforms and selective for both γ- and δ-isoforms, and a Bruton's tyrosine kinase (BTK) inhibitor. In some embodiments, the invention includes therapeutic methods of using a BTK inhibitor and a PI3K-δ inhibitor to treat solid tumor cancers by modulation of the tumor microenvironment, including macrophages, monocytes, mast cells, helper T cells, cytotoxic T cells, regulatory T cells, natural killer cells, myeloid-derived suppressor cells, regulatory B cells, neutrophils, dendritic cells, and fibroblasts.