The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2019

Filed:

Jan. 22, 2016
Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Thomas D. Bannister, Palm Beach Gardens, FL (US);

Hui Wang, Jupiter, FL (US);

Chao Wang, Palm Beach Gardens, FL (US);

John L. Cleveland, Land O' Lakes, FL (US);

Assignee:

The Scripps Research Institute, La Jolla, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 31/155 (2006.01); A61K 31/525 (2006.01); A61K 31/4985 (2006.01); C07D 475/02 (2006.01); C07D 475/00 (2006.01); A61P 37/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/155 (2013.01); A61K 31/4985 (2013.01); A61K 31/525 (2013.01); A61K 45/06 (2013.01); A61P 37/06 (2018.01); C07D 475/00 (2013.01); C07D 475/02 (2013.01); A61K 2300/00 (2013.01);
Abstract

The invention provides compounds effective as inhibitors of monocarboxylate transporters such as MCT1 and MCT4, which can be used for treatment of medical conditions wherein treatment of the condition with a compound having an inhibitor effect on MCT1, MCT4, or both is medically indicated. Compounds of the invention can have antitumor, antidiabetes, anti-inflammatory, or immunosuppressive pharmacological effects, and can be effective for treatment of cancer and of type II diabetes.


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