The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Aug. 24, 2016
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Giordano Caponigro, Foxborough, MA (US);
Thomas Horn-Spirohn, Cambridge, MA (US);
Joseph Lehar, Lexington, MA (US);
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/52 (2006.01); A61P 35/00 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01); A61K 31/661 (2006.01); A61K 31/4439 (2006.01); A61K 31/5517 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/5517 (2013.01); A61K 31/661 (2013.01); A61P 35/00 (2018.01);
Abstract
The present disclosure pertains to a pharmaceutical combination comprising (a) an alpha-isoform specific PI3K inhibitor, (b) a cyclin dependent kinase 4/6 (CDK4/6) inhibitor, and (c) an antimetabolite antineoplastic agent; combined preparations and pharmaceutical compositions thereof; the uses of such a combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.