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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10328058 B1

PDFFull Text
Date of Patent:
Jun. 25, 2019

Filed:

Oct. 24, 2017

Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques

Applicants:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Unity Biotechnology, Inc., Brisbane, CA (US);

Buck Institute for Research on Aging, Novato, CA (US);

Inventors:

Darren J. Baker, Rochester, MN (US);

Marco Demaria, Groningen, NL;

Albert Davalos, San Rafael, CA (US);

Bennett G. Childs, Rochester, MN (US);

Jan M. A. van Deursen, Rochester, MN (US);

James L. Kirkland, Rochester, MN (US);

Tamar Tchkonia, Rochester, MN (US);

Yi Zhu, Rochester, MN (US);

Nathaniel David, Brisbane, CA (US);

Remi-Martin Laberge, San Francisco, CA (US);

Judith Campisi, Berkeley, CA (US);

Assignees:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Unity Biotechnology, Inc., Brisbane, CA (US);

Buck Institute for Research on Aging, Novato, CA (US);

Attorneys:

Michael Schiff

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Theodore R West

Int. Cl.
CPC ...
A61P 9/10 (2006.01); A61K 31/496 (2006.01); A61K 31/4178 (2006.01); A61K 31/404 (2006.01); A61K 31/428 (2006.01); A61K 31/4375 (2006.01); A61K 31/5377 (2006.01); A61K 9/00 (2006.01); A61K 31/4164 (2006.01); A61K 45/06 (2006.01); A61K 47/36 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4178 (2013.01); A61K 9/0019 (2013.01); A61K 31/404 (2013.01); A61K 31/4164 (2013.01); A61K 31/428 (2013.01); A61K 31/4375 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61P 9/10 (2018.01); A61K 45/06 (2013.01); A61K 47/36 (2013.01); C12N 5/0081 (2013.01); C12N 2501/999 (2013.01);
Abstract

Foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines. In advanced lesions, senescent cells promote features of plaque instability, including elastic fiber degradation and fibrous cap thinning, by heightening metalloprotease production. This invention provides methods and materials for treating arthritis by removing senescent cells in or around atherosclerotic plaques, thereby stabilizing the plaques, inhibiting rupture of the plaques and pathological sequelae that manifest as coronary artery disease.

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