The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Jan. 27, 2015
Applicant:
Hovione International Ltd, Wanchai, Hong Kong, CN;
Inventors:
Eunice Costa, Santa Iris da Azoia, PT;
Marcio Temtem, Quinta do Conde, PT;
Luis Sobral, Loures, PT;
Constanca Cacela, Lisbon, PT;
Peter Villax, Lisbon, PT;
Assignee:
Hovione International Ltd., Wanchai, HK;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 225/04 (2006.01); C07D 333/16 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); A61K 9/14 (2006.01); A61K 9/00 (2006.01); A61K 31/439 (2006.01); A61K 31/56 (2006.01); A61K 31/522 (2006.01);
U.S. Cl.
CPC ...
A61K 9/14 (2013.01); A61K 9/0075 (2013.01); A61K 9/145 (2013.01); A61K 31/439 (2013.01); A61K 31/522 (2013.01); A61K 31/56 (2013.01);
Abstract
A new scalable process to control the particle size and the particle size distribution, comprising 5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv) stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.