Apparatus, method, and system for creating phylogenetic tree

Abstract

According to the present invention, a phylogenetic tree can be created on the basis of frequency data regarding a large number of mutations detected from the samples of a cancer. Each sample to be analyzed contains a mixture of plural clones having different genomes. Mutations having about the same frequencies are grouped to make plural groups, and an analysis is executed based on data listing the mutation frequencies of individual groups (called mutation group frequency data). It is assumed that pairs of clones corresponding respectively to mutation groups such that frequencies of one group is equal to or greater than that of another in all the samples have parent-child relations, and a graph structure having the clones as vertices and the parent-child relations as edges is created. In this graph, parent-child relations contradictory to the mutation group frequency data are removed, and a clone to become a parent is selected in consideration of correlation coefficients among the mutation group frequencies in the samples.