The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2019
Filed:
Apr. 07, 2016
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Peter Bruenker, Hittnau, CH;
Christiane Neumann, Niederweningen, CH;
Christian Klein, Bonstetten, CH;
Ekkehard Moessner, Kreuzlingen, CH;
Wolfgang Schaefer, Mannheim, DE;
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
Multispecific antibodies based on antibodies that share a common light chain are described herein. The multispecific antibodies include: modified heavy chains having, by domain exchange, a common light chain variable domain VL; and two modified light chains having, by domain exchange, variable heavy chain domains of a first antibody (VH) and a second antibody (VH), wherein one light chain is of kappa isotype and one light chain is of lambda isotype. The present invention also relates to methods for the manufacture of such antibodies and their use.