The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2019
Filed:
Jul. 06, 2012
Applicants:
Paul Parren, Odijk, NL;
Patrick Van Berkel, Utrecht, NL;
Ewald T. J. Van Den Bremer, Eindhoven, NL;
Inventors:
Assignee:
GENMAG A/S, Copenhagen V, DK;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/00 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 16/00 (2013.01); G01N 33/5014 (2013.01); G01N 33/6854 (2013.01); C07K 2317/51 (2013.01); C07K 2317/52 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/734 (2013.01);
Abstract
Provided are antibody variants having decreased or increased ability to mediate complement-dependent cytotoxicity (CDC) due to the presence or absence of C-terminal lysines of their heavy chains. Also provided are methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of such antibodies.