The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2019
Filed:
Sep. 17, 2015
Affibody Ab, Solna, SE;
Lars Abrahmsén, Stockholm, SE;
Caroline Ekblad, Saltsjö-boo, SE;
Elin Gunneriusson, Saltsjöbaden, SE;
Torbjörn Gräslund, Hägersten, SE;
Johan Seijsing, Stockholm, SE;
John Löfblom, Huddinge, SE;
Malin Lindborg, Saltsjö-boo, SE;
Fredrik Frejd, Stockholm, SE;
Lindvi Gudmundsdotter, Stockholm, SE;
AFFIBODY AB, Solna, SE;
Abstract
The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein the first and second monomer units each comprises an FcRn binding motif. The FcRn binding dimer binds FcRn with higher capacity compared to the first monomer unit or second monomer unit alone. The present disclosure also relates to the use of the FcRn binding dimer as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.