The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2019
Filed:
Apr. 01, 2016
Applicant:
Crystal Pharmatech Co., Ltd, Suzhou, Jiangsu, CN;
Inventors:
Minhua Chen, Jiangsu, CN;
Yanfeng Zhang, Suzhou, CN;
Qiyue Liu, Jiangsu, CN;
Nan Xia, Jiangsu, CN;
Chaohui Yang, Jiangsu, CN;
Xiaoyu Zhang, Jiangsu, CN;
Assignee:
Crystal Pharmatech Co., Ltd., Suzhou, Jiangsu, CN;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/4184 (2006.01); A61K 31/519 (2006.01); C07D 235/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4184 (2013.01); A61K 31/519 (2013.01); C07D 235/06 (2013.01); C07B 2200/13 (2013.01);
Abstract
The present disclosure relates to novel co-crystals of a CDK inhibitor and an MEK inhibitor and the preparation methods thereof. Specifically, the present disclosure provides hydrates or anhydrates which are named as Form I, Form II and Form III. The novel co-crystals provided in the present disclosure have good stability, low hygroscopicity and high solubility, and have an important value for further optimization and development of the drug.