The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2019
Filed:
Oct. 07, 2016
Applicant:
Nant Holdings Ip, Llc, Culver City, CA (US);
Inventors:
Ting Wu, Culver City, CA (US);
Kayvan Niazi, Encino, CA (US);
Assignee:
NANT HOLDINGS IP, LLC, Culver City, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 41/00 (2006.01); A61K 31/708 (2006.01); A61K 38/05 (2006.01);
U.S. Cl.
CPC ...
A61K 41/00 (2013.01); A61K 31/708 (2013.01); A61K 38/05 (2013.01); A61K 41/0028 (2013.01);
Abstract
Systems and methods of inducing large-scale optical transfection and generation of an immune response in target cells are presented. In preferred aspects large-scale optofection uses nanoparticles with target specific affinity moieties to generate cavitation events proximal to the cell membrane of cells to which the nanoparticles are attached, and suspended and/or dissolved cargo is so provided access into the cell. Notably, cells can be transfected in very large quantities at high viability, with the transfected cells exhibiting up-regulated immune responses.